Differential diagnosis between primary psychiatric syndromes (non-degenerative/functional disorders e.g. depression) and different types of neurocognitive disorders (neurodegenerational disorders e.g. Alzheimer’s disease) can be very challenging in clinical practice due to the fact that current diagnosis methodologies are based on a subjective classification by the neuropsychologist, radiologist, nuclear radiologist, as well as by the clinician who integrates all different types of available information. Diagnoses are thus based on subjective interpretations of neural, cognitive, emotional and behavioral changes in the patient, measured via different types of data modalities.